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A complete of three % of Lively compound is excreted in urine as unchanged Energetic substance. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, which are additional metabolised by conjugation. Hence, Lively substance metabolism mediated by cytochrome P450 pr